By Nancy L. Geller

ISBN-10: 0824790324

ISBN-13: 9780824790325

From elements of early trials to complicated modeling difficulties, this helpful reference summarizes present technique utilized in the layout and research of scientific trials. Chapters are contributed through the world over respected methodologists skilled in scientific trials perform.

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Extra info for Advances in Clinical Trial Biostatistics

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Critical role of phase I clinical trials in cancer treatment. Journal of Clinical Oncology 15:853–859. , Zacks, S. (1998). Cancer phase I clinical trials: Efficient dose escalation with overdose control. Statistics in Medicine 17:1103–1120. Babb, J. , Rogatko, A. (2001). Patient specific dosing in a cancer phase I clinical trial. Statistics in Medicine 20:2079–2090. , Larntz, K. (1989). Optimal Bayesian design applied to logistic regression experiments. Journal of Planning and Inference 21:191–208.

Dent, S. , Eisenhauer, E. A. (1996). Phase I trial design: Are new methodologies being put into practice? Annals of Oncology 6:561–566. Dillman, R. , Koziol, J. A. (1992). Phase I cancer trials: Limitations and implications. Molecular Biotherapy 4:117–121. Eichhorn, B. , Zacks, S. (1973). Sequential search of an optimal dosage I. Journal of American Statistical Association 68:594–598. Copyright n 2004 by Marcel Dekker, Inc. All Rights Reserved. Bayesian Methods for Cancer Phase I Clinical Trials 37 Eichhorn, B.

Phase I cancer trials: Limitations and implications. Molecular Biotherapy 4:117–121. Eichhorn, B. , Zacks, S. (1973). Sequential search of an optimal dosage I. Journal of American Statistical Association 68:594–598. Copyright n 2004 by Marcel Dekker, Inc. All Rights Reserved. Bayesian Methods for Cancer Phase I Clinical Trials 37 Eichhorn, B. , Zacks, S. (1981). Bayes sequential search of an optimal dosage: Linear regression with both parameters unknown. Communications in Statistics-Theory and Methods 10:931–953.

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Advances in Clinical Trial Biostatistics by Nancy L. Geller


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