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Not only does anxiety feel different, but at a purely neurological level, it z's different. Evidence for this comes from experience with a family of drugs called ben/odiaxepines, of which Valium is the most well known. At low to moderate doses, these drugs sig- Your Brain on Alcohol I 53 nificantly reduce anxiety without impairing or disrupting other brain systems. Valium works by enhancing the function of a receptor that plays yin to glutamate's yang in the brain. Instead of passing on a message to "fire," this receptor makes it harder for a neuron to fire.

30 / Buzz Clearly, these genes did not just magically appear with the advent of the human discovery of fermentation. The answer to these questions lies in our guts. The helpful bacteria that populate our intestines often work under conditions similar to those experienced by yeast at the bottom of fermentation vats. Deprived of oxygen, these bacteria produce minute amounts of ethanol as a result of anaerobic metabolism. Apparently, natural selection favored creatures that could get rid of these tiny quantities of ethanol.

Closed ion channel, cross section. (Ann Bliss Pilcher) cculc detaches and the ion channel resumes its normal closed shape. If enough ion channels open at approximately the same time (as is happening now from the sudden influx of scotch) the electrical balance of the entire taste receptor is tipped so much that nearby nerves are stimulated. In this case, those nerves hre off a message that is interpreted in the brain as mildly bitter. Perhaps the molecules we've been looking at, then, arc sharp-tasting tannins derived, originally, from the oak sheaves of the sherry casks.

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