By Arthur K. Cho, Terrence F. Blaschke, Paul A. Insel, Horace H. Loh
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Exploring the research of prescribed drugs, together with polymorphic kinds, this booklet discusses regulatory necessities in pharmaceutical product improvement and pharmaceutical checking out. It covers equipment of drug separation and methods akin to capillary electrophoresis for chromatographic separation of molecules.
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Extra resources for Annual Review of Pharmacology and Toxicology Volume 45, 2005 (Annual Review of Pharmacology and Toxicology)
Res. Toxicol. 5:585–90 Klehr H, Eyer P, Sch¨afer W. 1987. Formation of 4-ethoxy-4 -nitrosodiphenylamine in the reaction of the phenacetin metabolite 4-nitrosophenetol with glutathione. Biol. Chem. Hoppe-Seyler 368:895–902 Eyer P. 1988. Detoxication of Noxygenated arylamines in erythrocytes. An overview. Xenobiotica 18:1327–33 Mandell GL, Sande MA. 1985. Antimicrobial agents: sulfonamides, trimethoprim-sulfamethoxazole and agents for urinary tract infections. In The Pharmacological Basis of Therapeutics, ed.
USA 76: 5929–33 Fuscoe JC, Wu R, Shen NH, Healy SK, Felton JS. 1988. Base-change analysis of revertants of the hisD3052 allele in Salmonella typhimurium. Mutat. Res. 201:241–51 Sugimura T. 1997. Overview of carcinogenic heterocyclic amines. Mutat. Res. 376:211–19 Kosakarn P, Halliday JA, Glickman BW, Josephy PD. 1993. Mutational specificity of 2-nitro-3,4-dimethylimidazo[4,5-f] quinoline in the lacI gene of Escherichia coli. Carcinogenesis 14:511–17 Watanabe M, Ohta T. 1993. Analysis of mutational specificity induced by heterocylic amines in the lacZ gene of Escherichia coli.
Boca Raton, FL: CRC Press 32. Frederick CB, Mays JB, Ziegler DM, Guengerich FP, Kadlubar FF. 1982. Cytochrome P-450 and flavin-containing monooxygenase-catalyzed formation of the carcinogen N-hydroxy-2-aminofluorene, and its covalent binding to nuclear DNA. Cancer Res. 42:2671–77 33. Hammons GJ, Guengerich FP, Weis CC, Beland FA, Kadlubar FF. 1985. Metabolic oxidation of carcinogenic arylamines by rat, dog, and human hepatic microsomes and by purified flavin-containing and cytochrome P-450 monooxygenases.
Annual Review of Pharmacology and Toxicology Volume 45, 2005 (Annual Review of Pharmacology and Toxicology) by Arthur K. Cho, Terrence F. Blaschke, Paul A. Insel, Horace H. Loh
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